본 논문은 pCTI05로 유도된 치매모델에서 석창포(石菖蒲) 수추출액(水抽出液)이 미치는 영향에 관한 것이다. 석창포 수추출액을 이용하여 항치매 효과를 규명하기 위하여 APP의 pCT105로 유도된 신경세포암 세포주에 석창포의 수추출액을 반응시켜 본 결과, 석창포의 수추출물은 $\beta$ APP의 CT105발현 신경아세포암 세포주의 세포사를 효과적으로 억제하고 신경세포를 보호하는것으로 분석되어, 치매 등의 다양한 뇌질환에 임상응용으로 접목 가능할 것으로 사료된다는 내용이다
Alzheimer's disease(AD) is a geriatric dementia that is widespread in old age. In the future AD will be the largest problem in public health service. From old times, Much medicines have been used for treatment of dementia, but there is no medicine having obvious effect. AD is one of brain retrogression disease. So We studied on herbal medicine that have a relation of brain retrogression. From old times, In Oriental Medicine, Rhizoma Acori Graminei has been used for disease in relation to brain retrogression. We studied on the effects of anti-Alzheimer in pCT105-induced neuroblastoma cell lines by Rhizoma Acori Graminei extract As the result of this study, In RAG group, the apoptosis in the nervous system is inhibited, the repair against the degerneration of Neuroblastoma cells by CT105 expression is promoted. These results indicate that RAG possess strong inhibitory effect of apoptosis in the nervous system and repair effect against the degeneration of Neuroblastoma cells by CT105 expression.
